Spider-Man 2 (the Sam Rami movie one) is almost a totally different game.
There is also a ton of between-consoles differences from the SNES/Genesis generation, where games with the same title are sometimes radically different. Jurassic Park, Star Trek TNG, and the Power Rangers brawler come to mind.
“Robot is sleepy.”
Do you want me to wake it up?
“NNNNOOOOOOoooooo!”